In 2017, the Union for the Mediterranean (UfM) adopted the Cairo Ministerial Declaration to strengthen the role of women in society. Since then, it has worked ceaselessly to achieve the objectives of the declaration, in a very complicated environment that has also been aggravated by crises such as the Covid-19 pandemic, climate change or the war in Ukraine. On 26 October 2022, the UfM hopes to adopt a new declaration based on three main thematic areas: women’s economic empowerment in contexts of regional crises, gender equality and climate change, and violence against women and girls (VAWG). The governments of the member states of the UfM, as well as the civil society partners and associations, are all key players to continue working together along these lines and confront the challenges of the region.